Senior Manager/Associate Director, Commercial & Medical Information Systems

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting, and continue to advance an early-stage pipeline of novel therapeutic candidates. In 2025, we initiated Phase 1 trials for XEN1701 (targeting Nav1.7) and XEN1120 (targeting Kv7). Nav1.7 and Kv7 are important pain targets, and data from these Phase 1 studies are expected in 2026 to support Phase 2 proof-of-concept studies in acute pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About The Role

We are seeking a Senior Manager/Associate Director, Commercial & Medical Information Systems, to join our Information Technology (IT) team. The Senior Manager/Associate Director, Commercial & Medical Information System will partner with leaders across Commercial and Medical, and other functions as needed to drive adoption, operations, and ongoing enhancements to the IT systems and support the implementation and management of the Commercial and Medical IT system. The ideal candidate has a strong understanding of Commercial and Medical business processes, with prior experience with the Veeva suite of products, Commercia Data Warehouse, and other key Commercial and Medical IT systems for current and future needs.

The position reports to the Director, Commercial & Medical Information Systems and will be based out of Boston, MA, USA in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week.

RESPONSIBILITIES:

• Partner with functional stakeholders and vendors to build new solutions supporting the Commercial and Medical functions, including integrations between systems and between Xenon and key service providers.

• Author, review, and approve applicable SDLC deliverables, and coordinate assurance and other testing activities.

• Develop, review, and approve procedures defining System Administration activities.

• Collaborate with Xenon’s Architecture Review Board to ensure the system design is consistent with company standards for security, infrastructure, and data architecture.

• Manage and execute day-to- day operations and configuration of the Veeva Commercial suite (CRM, Network, OpenData, etc.), andthe day-to-day operations and configuration of other Commercial and Medical IT systems (Publications, MedComms, etc.).

• Ensure system administration and configuration, including workflows, metadata, security, reference data, page layouts, and system settings.

• Perform user administration and manage licensing across Commercial and Medical IT systems. Support user onboarding, system training, and operational adoption from a system and process perspective.

• Collaborate with data stewards to manage master data management activities, including management of HCPs, HCOs, and associated affiliation data.

• Collaborate with key stakeholders to develop and maintain roadmaps, continuous improvement initiatives, and system standardization efforts.

• Manage vendor/MSP relationships related to IT systems.

• Provide technical guidance and support on change control activities.

• Ensure ongoing compliance with Xenon procedures including SaaS Release Management, Change Management, Problem Management, etc.

• Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.

• Other duties as assigned.

QUALIFICATIONS:

• Bachelor’s degree in Information Systems, Computer Science, Business Administration or related field.

• Minimum of 5 years of relevant experience, preferably in the Life Sciences industry. Experience supporting pre-commercial or early commercial biotech organizations preferred.

• Proven experience with the Veeva suite of products, Commercial Data Warehouse technology, and other key Commercial and Medical IT systems (Veeva certification a plus).

• Strong understanding of the Commercial and Medical business processes.

• Knowledge of user management administration.

• Proficiency supporting commercial data platforms and downstream analytics.

• Experience managing vendors/MSPs and collaborating with business stakeholders to prioritize support or enhancement requests.

• Experience with system integrations (APIs, data flows, connectors).

• Excellent communication and coordination skills across business and technical teams.

• Ability to manage multiple priorities in a fast-paced environment.

• Strong problem-solving skills and attention to detail.

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.