Senior Director, Market Access

Location:  This position may be performed remotely, but requires the flexibility and willingness to travel as needed.The OpportunityPraxis is seeking a bold, analytical builder to serve as Senior Director of Market Access. This is not a policy or oversight role.  We’re seeking a person who is ready to roll up their sleeves and build Market Access infrastructure from the ground up across two distinct launches within the next 12 – 15 months.  You'll support the launches of Ulixacaltamide (a large-market, Medicare-heavy asset in Essential Tremor), and Relutrigine (an ultra-rare, pediatric, Medicaid-heavy asset).  You will lead strategy and execution across pricing, contracting, evidence generation, and payer engagement.  The role requires someone comfortable defending value in front of leadership, owning deliverables under pressure, and shaping governance with a small, fast-moving team. The ideal candidate is a high-output operator with deep curiosity, sharp judgment, and the ability to move from insight to action – fast. Primary Responsibilities<ul><li>Own and execute U.S. pricing strategy including analog analysis, GTN modeling, value defense, and scenario planning. </li><li>Develop actionable contracting strategies (Medicaid, Medicare, Commercial), in close coordination with Finance, Trade, and Legal. </li><li>Drive HEOR and value story development, including burden of disease, cost-offset, and payer-relevant evidence to support access and reimbursement. </li><li>Lead key Market Access governance processes, including pricing committee workflows, PIE timelines, and contracting review forums. </li><li>Develop foundational payer engagement tools including AMCP dossiers, policy intelligence, and payer materials for use in pre- and post-launch. </li><li>Conduct and synthesize competitive and policy intelligence, including FOIA scans, Medicaid policy analysis, and payer environment. </li><li>Serve as Market Access lead on cross-functional workstreams, contributing strategic insight and executional muscle across Commercial, Medical Affairs, and Program Teams. </li></ul>Qualifications and Key Success Factors<ul><li>Bachelor’s degree required; advanced degree in business, public health, or science strongly preferred. </li><li>10+ years of biotech/pharma or consulting experience with recent hands-on focus in U.S. market access. Global experience a plus but not required. </li><li>Direct launch experience in both rare and common disease indications. Prior work with Medicaid-heavy and Medicare-heavy assets is essential. </li><li>Demonstrated strength in building market access infrastructure, not just managing it, especially in lean or resource-constrained environments. </li><li>Strong analytical and strategic chops, able to self-structure, distill complexity, and make recommendations with incomplete data. </li><li>Excellent communication and storytelling skills; capable of making a compelling, data-driven case to diverse internal and external stakeholders. </li><li>High bias for action, with the judgment to balance autonomy and alignment in a fast-paced, feedback-rich environment. </li><li>Deep alignment with Praxis values of Trust, Ownership, Curiosity, and Results.</li><li>The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement.  You'll need comfort with screen work, basic hand coordination, and focus.  Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.</li></ul>Compensation & BenefitsAt Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive.  This includes 99% of the premium paid for medical, dental and vision plans.  We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future?  We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP.  We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns.  Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring.  We aim high, collaborate hard, and produce results.  Let’s achieve the impossible together! To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below.  Final salary range may be modified commensurate with job level, education, and experience.<div class="content-pay-transparency"><div class="pay-input"><div class="title">Annualized Base Salary</div><div class="pay-range">$270,000—$295,000 USD</div></div></div><div class="content-conclusion">Company Overview Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance.  At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders.  Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members. Diversity, Equity & Inclusion Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws. Attention: Job Scam Alert Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to <a href="mailto:careers@praxismedicines.com">careers@praxismedicines.com</a>. Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.</div>

Senior Director, Market Access

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