Senior Director / Executive Director, Clinical Operations

This position is posted by Jobgether on behalf of a partner company. We are currently looking for a Senior Director / Executive Director, Clinical Operations in United States.

This leadership role sits at the core of building and scaling clinical operations for an innovative oncology program developing next-generation targeted cancer therapies. You will be the foundational hire responsible for shaping clinical operations strategy while directly overseeing the execution of a Phase 1/2 study in a fast-moving biotech environment. Acting as both a hands-on operator and strategic leader, you will ensure trials are delivered on time, within budget, and to the highest scientific and regulatory standards. You will build the clinical operations function from the ground up, establishing systems, SOPs, and scalable processes to support future pipeline growth. The role requires close collaboration with clinical, regulatory, and executive leadership teams, with direct reporting to the Chief Medical Officer. This is a high-impact opportunity to contribute directly to advancing breakthrough cancer therapies with the potential to transform patient outcomes.

Accountabilities:

In this role, you will lead end-to-end clinical operations for oncology programs while building the foundational infrastructure needed for scalable growth.

Lead execution of Phase 1/2 oncology clinical trials, ensuring timely, high-quality, and budget-compliant delivery
Build and scale the clinical operations function, including hiring, onboarding, and mentoring initial team members
Develop and implement SOPs, operational frameworks, and systems to support clinical trial execution and future expansion
Oversee clinical trial budgeting, forecasting, and resource allocation, ensuring financial discipline and risk management
Manage CROs and external vendors, including selection, contract negotiation, oversight, and performance management
Drive study planning, risk mitigation, and scenario planning to proactively address operational challenges
Collaborate cross-functionally with clinical, scientific, and executive stakeholders to align strategy and execution

Requirements:

This position requires deep experience in clinical operations within biotech or pharmaceutical environments, particularly in oncology and early-phase trials.

10+ years of experience in pharma or biotech clinical operations, including at least 5+ years in oncology (Phase 1 and 2 studies required)
Proven experience leading end-to-end global clinical trials, including startup, execution, and database lock
Track record of building and scaling clinical operations teams in early-stage or high-growth biotech environments
Strong expertise in CRO and vendor management, including contracting and performance oversight
Solid financial acumen with experience in budgeting, forecasting, and resource planning for clinical programs
Strong analytical and organizational skills, with proficiency in tools such as Excel, MS Project, or Smartsheet
Ability to operate in high-ambiguity environments with strong decision-making and problem-solving capabilities
Excellent communication and executive presence, with experience presenting to senior leadership and stakeholders
Hands-on leadership style with the ability to balance strategic thinking and operational execution

Benefits:

Competitive base salary range of $250,000 – $300,000 USD
Equity participation as part of total compensation package
Comprehensive medical, dental, and vision insurance
401(k) retirement plan with company match
Short-term and long-term disability coverage
Flexible paid time off (PTO) and remote-first work model
Work-from-home stipend to support remote setup
Professional development, mentorship, and growth opportunities
Exposure to cutting-edge oncology innovation and high-impact clinical programs

How Jobgether works:

We use an AI-powered matching process to ensure your application is reviewed quickly, objectively, and fairly against the role's core requirements. Our system identifies the top-fitting candidates, and this shortlist is then shared directly with the hiring company. The final decision and next steps (interviews, assessments) are managed by their internal team.

We appreciate your interest and wish you the best!

Why Apply Through Jobgether?

Data Privacy Notice: By submitting your application, you acknowledge that Jobgether will process your personal data to evaluate your candidacy and share relevant information with the hiring employer. This processing is based on legitimate interest and pre-contractual measures under applicable data protection laws (including GDPR). You may exercise your rights (access, rectification, erasure, objection) at any time.

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Senior Director / Executive Director, Clinical Operations

Requirements:

Benefits:

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