PK/PD Principal Scientist

In this role, you will lead the design, execution, and interpretation of in vivo PK/PD and toxicokinetic studies across multiple veterinary species, ensuring scientific rigor and translational relevance. You will contribute to advancing drug development programs through modeling, strategic input, and cross-functional collaboration.

• Independently design, analyze, and interpret in vivo PK, PK/PD, and TK studies, including development of protocols and scientific reports across multiple animal species
• Apply PK/PD modeling and simulation approaches to support lead candidate selection, dose optimization, and translational decision-making
• Collaborate with bioanalytical teams to assess assay suitability and define analytical requirements for development programs
• Lead scientific strategy development across therapeutic areas, focusing on biomarkers, target engagement, and translational modeling approaches
• Partner with multidisciplinary teams to design and execute studies aligned with project and regulatory objectives
• Present scientific findings to internal stakeholders, senior leadership, and external regulatory agencies
• Contribute to regulatory documentation, respond to agency inquiries, and ensure alignment with applicable guidelines and standards

Requirements

The ideal candidate is an experienced pharmacology scientist with strong expertise in PK/PD modeling, in vivo study design, and translational drug development within pharmaceutical or veterinary research environments.

• PhD in pharmacology, biochemistry, or related discipline with 4+ years of relevant pharmaceutical development experience
• Strong expertise in designing, analyzing, and interpreting in vivo PK and PK/PD studies; experience in biotherapeutics is highly preferred
• Proficiency with PK/PD modeling software such as WinNonlin, Monolix, Watson, NONMEM, or R-based tools
• Experience in PK/PD modeling approaches such as PBPK, QSP, or population PK modeling is highly desirable
• Working knowledge of bioanalytical methods, including immunogenicity and ADA assay assessment
• Experience interacting with regulatory agencies and contributing to regulatory submissions is highly valued
• Strong communication skills with the ability to present complex scientific concepts clearly to diverse audiences
• Self-starter with strong organizational skills and the ability to work independently in a fast-paced environment
• Experience with GLP studies and advanced veterinary pharmacology certifications (e.g., DVM DACVCP, ECVPT) is a plus

Benefits

• Competitive base salary ranging from $114,000 to $185,000 depending on experience and location
• Eligibility for short-term and long-term incentive compensation programs
• Comprehensive health, dental, and vision insurance starting on day one
• 401(k) retirement plan with company match and profit-sharing contributions
• Four weeks of paid vacation plus additional paid time off benefits
• Robust wellbeing programs supporting physical, emotional, and financial health
• Opportunities to contribute to cutting-edge veterinary drug discovery and development
• Equal opportunity workplace with strong commitment to diversity, inclusion, and accessibility.