<div class="content-intro"><p>Spyre Therapeutics is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease (“IBD”) and rheumatic diseases. Spyre's pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, and IL-23.</p></div><p><strong>Role Summary:</strong></p><p>The Executive Director of Program Management will play a crucial role in the planning and execution of our development programs. This position requires a proactive individual who thrives in a dynamic, rapidly growing startup environment.</p><p><strong>Key Responsibilities:</strong></p><ul><li>Meticulously maintain and track detailed integrated program timelines ensuring alignment across functions on dependencies and assumptions crucial for corporate goals. Recognize and alert stakeholders when projects are on or near critical paths to key milestones. Communicate progress transparently and address issues promptly.</li><li>Manage cross-functional meetings efficiently, ensuring clear objectives, documenting outcomes, information, and action items, and following up on tasks with team members. </li><li>Develop and upkeep project documentation including meeting materials, minutes, action item logs, decision trackers and dashboards.</li><li>Proactively identify, monitor, communicate and propose mitigation options for program risks. </li><li>Collaborate across functions including Pre-clinical, Clinical Development, Technical Operations, Regulatory, Quality, Finance and Legal to ensure alignment.</li><li>Play a pivotal role within the Portfolio Management and Operations team, providing guidance on best practices, developing team resources, tools and templates, and nurturing a culture of excellence, innovation, and accountability.</li><li>Other duties as assigned</li></ul><p><strong>Ideal Candidate:</strong> </p><ul><li>Demonstrated proficiency in overseeing complex development programs, guiding them from Investigational new Drug IND) stage through Phase 2 clinical development, with a strong preference for monoclonal antibody therapeutics experience.</li><li>Bachelor’s degree in a science-related field required; an advanced degree is preferred.</li><li>Minimum of 10 years of relevant experience in biotechnology or pharmaceuticals, with at least 5 years directly in program management.</li><li>Strong planning skills, critical thinking abilities and keen attention to detail.</li><li>Ability to juggle multiple tasks, adapt to shifting priorities in a fast-paced environment.</li><li>Excellent facilitation, communication, and leadership skills</li><li>Strong interpersonal skills and the ability to interact well with all employee levels</li><li>Expert in creating Gantt charts in Smartsheet, Think-Cell and Office Timeline Pro+ software, along with report generation.</li><li>In-depth understanding of the drug development process, regulatory requirements, and industry standards.</li><li>Willingness to travel up to 10% annually, including quarterly all hands meetings and ad hoc development team gatherings.</li></ul><p><strong>What We Offer:</strong></p><ul><li>Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.</li><li>Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits.</li><li>Unlimited PTO</li><li>Two, one-week company-wide shutdowns each</li><li>Commitment to provide professional development opportunities.</li><li>Remote working environment with frequent in-person meetings to address complex problems and build relationships.</li></ul><p>The expected salary range offer for this role is $295,000 to $313,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location. </p><div class="content-conclusion"><p>As an equal opportunity employer, Spyre is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients.</p><p>Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “@spyre.com.” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.</p><p>Please also be aware that all job postings will be listed on our website at spyre.com/careers/.</p></div>